摘 要：以濕法消解對低硼硅玻璃安瓿瓶包裝的燈盞花素葡萄糖注射液進行消解，建立ICP-AES及ICP-MS測定其中Al、Ca、K、Na等14種元素的方法，并從檢出限、定量限、重復(fù)性等方面進行驗證。結(jié)果表明：該方法檢出限為0.009 ng/mL（Ni）～0.03 μg/mL（Al）；定量限為0.03 ng/mL（Ni）～0.09 μg/mL（Al）。平均加標(biāo)回收率介于95.6%～101.4%之間。
關(guān)鍵詞：燈盞花素；元素遷移；ICP-AES；ICP-MS
文獻標(biāo)志碼：A 文章編號：1674-5124（2015）12-0036-05
Study on element migration in ampoules of scutellarin glucose injection
LvHao1，2， ZHANG Yulan1， SUN Yujie1， OUYANG Yuping3， SUN Siyang1， HU Yaqin1
（1. National Institute of Measurement and Testing Technology，Chengdu 610021，China；
2. Analytical and Testing Center of Sichuan University，Chengdu 610061,China；
3. Jilin Sichang Pharmaceutical Limited Company，Meihekou 135000，China）
Abstract: A method with ICP-AES and ICP-MS has been established to determine the Al， Ca， K and Na and ten other elements in scutellarin glucose injection contained in low-borosilicate glass ampoules by means of wet digestion. The method has been verified in respect to detection limit， quantitative limit， repeatability， etc. The detection limit is 0.009 ng/mL（Ni）-0.03 μg/mL（Al）， the quantitative limit is 0.03 ng/mL（Ni）-0.09 μg/mL（Al）， and the average recovery is 95.6%-101.4%.
Keywords: scutellarin； element migrate； ICP-AES； ICP-MS
